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PAH: Moderate to Severe

Why is it important to know your risk status?

Improving risk status in a timely manner is an essential goal, as having a lower risk status may help improve the outcomes in some patients.

Your risk status tells your doctor how you’re doing today and whether your disease is getting better, staying the same, or getting worse. When PAH gets worse, it’s called disease progression. Your doctor uses risk status to make decisions about your care.

To determine your risk status, your doctor looks at many different measures, such as the function of the right side of your heart and your 6-minute walk test.

Risk status is divided into 3 levels of severity:

Categories of risk status severity: low (mild), intermediate (moderate) and high risk (severe PAH)

If your level of risk is high or intermediate, there is more of a chance that your disease may already be severe, and you should speak to your doctor about this.

Low risk means that there's a low chance of your PAH getting worse over the next 12 months. Achieving low risk, or mild PAH, within the first 3-6 months after your diagnosis should be the goal, as it is associated with better outcomes.

UNDERSTANDING SEVERE PAH

Knowing your risk status is important. Severe PAH can lead to a higher probability of heart failure if left untreated.

Symptoms of Severe PAH, like Mild and Moderate PAH, include things like shortness of breath, fatigue, dizziness, fainting, swelling, chest pain, and poor heart function. However, with Severe PAH, these symptoms can start to feel worse over time. If you're experiencing any of the symptoms listed, be sure to talk to your doctor about them.

Most People Have Moderate PAH

Did you know that almost 87% of people have moderate or severe PAH when they're diagnosed? And most are still in the same risk category when they see their doctor again.

Many people fall within this category, with some at intermediate-low risk, others at intermediate-high risk, and some nearing or reaching high risk.

No matter your risk status, it's important for your doctor to monitor your disease every 3-6 months so that you can work together to meet your specific goals.

Mild PAH Is The Goal For Many

Your doctor may consult guidelines to help you manage your PAH based on your current level of risk. The goal of these guidelines is to help you achieve mild PAH, or low-risk status, which may help improve your outlook.

Especially for those with severe PAH, it is recommended you check in with your doctor every 3-6 months to monitor your risk status and see how you're feeling. By staying on top of this, you and your doctor can make more informed decisions about your care.

Go learn as much as you can. When you have your doctor appointments, bring a notepad and have someone go with you who can take notes and help you with all the information.

—A patient with PAH

Get more advice from people living with PAH.

Read Patient Tips

Why it’s important to prioritize your heart function

Remodulin^® (treprostinil) Injection

Important Safety Information for Remodulin

Before you take Remodulin, tell your healthcare provider if you:

Have other medical conditions or take other medicines that may affect your use of Remodulin by increasing the risk of side effects or decreasing the drug’s effectiveness.
Have liver problems. Your Remodulin dose may need to be adjusted if you have liver problems.
Have low blood pressure or bleeding problems.
Are taking gemfibrozil (for high cholesterol), rifampin (for infection) or other drugs that affect liver enzymes. Your doctor may need to adjust your Remodulin dosage.
Are pregnant, breastfeeding, or planning to become pregnant. It is not known if Remodulin will harm your unborn baby or if Remodulin passes into your breast milk.

What are the serious side effects of Remodulin?

Continuous intravenous (IV) infusions of Remodulin delivered using an external infusion pump, with a tube placed in a central vein within the chest, are associated with the risk of blood stream infections and sepsis, which may be fatal. Therefore, continuous subcutaneous (SC) infusion delivered just beneath the skin is the preferred type of delivery.
Worsening of PAH symptoms. Do not stop taking or greatly reduce your Remodulin dose without consulting your doctor.
Low blood pressure (symptomatic hypotension). If you have low blood pressure or are taking drugs that lower your blood pressure, the risk of low blood pressure is increased.
Bleeding problems. Remodulin may increase the risk of bleeding in people who take blood thinners (anticoagulants).

What are the possible side effects of Remodulin?

In clinical studies of SC infusion of Remodulin, most people experienced infusion site pain and infusion site reaction (redness, swelling, and rash). These symptoms were sometimes severe and sometimes required treatment with narcotics or discontinuation of Remodulin.
IV infusion of Remodulin delivered through an external pump has been associated with the risk of blood stream infections, arm swelling, tingling sensations, bruising, and pain.
The most common side effects seen with either SC or IV Remodulin were headache, diarrhea, nausea, rash, jaw pain, widening of the blood vessels (vasodilatation), and swelling from fluid retention (edema). These are not all the possible side effects of Remodulin. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at www.fda.gov/MedWatch or call 1-800-FDA-1088.

What is Remodulin?

Remodulin is a prescription medication used to treat adults with pulmonary arterial hypertension (PAH; WHO Group 1), which is high blood pressure in the arteries of your lungs. Remodulin can reduce symptoms associated with exercise. Remodulin was studied mainly in patients with NYHA Functional Class II-IV symptoms. It is not known if Remodulin is safe and effective in children.

In people with PAH who need to switch from epoprostenol, Remodulin is approved to slow the worsening of symptoms.

The risk information provided here is not comprehensive. To learn more about Remodulin, talk with your healthcare provider. Please see Full Prescribing Information at www.remodulin.com or call Customer Service at 1-844-UNITHER (1-844-864-8437).

To learn more about Remodulin, talk with your healthcare provider. Please see Full Prescribing Information at www.remodulin.com or call Customer Service at 1-844-UNITHER (1-844-864-8437).

REMISIconFEB2025

PAH=pulmonary arterial hypertension; WHO=World Health Organization.

Remodulin^® (treprostinil) Injection

Important Safety Information for Remodulin

Before you take Remodulin, tell your healthcare provider if you:

Have other medical conditions or take other medicines that may affect your use of Remodulin by increasing the risk of side effects or decreasing the drug’s effectiveness.
Have liver problems. Your Remodulin dose may need to be adjusted if you have liver problems.
Have low blood pressure or bleeding problems.
Are taking gemfibrozil (for high cholesterol), rifampin (for infection) or other drugs that affect liver enzymes. Your doctor may need to adjust your Remodulin dosage.
Are pregnant, breastfeeding, or planning to become pregnant. It is not known if Remodulin will harm your unborn baby or if Remodulin passes into your breast milk.

What are the serious side effects of Remodulin?

Continuous intravenous (IV) infusions of Remodulin delivered using an external infusion pump, with a tube placed in a central vein within the chest, are associated with the risk of blood stream infections and sepsis, which may be fatal. Therefore, continuous subcutaneous (SC) infusion delivered just beneath the skin is the preferred type of delivery.
Worsening of PAH symptoms. Do not stop taking or greatly reduce your Remodulin dose without consulting your doctor.
Low blood pressure (symptomatic hypotension). If you have low blood pressure or are taking drugs that lower your blood pressure, the risk of low blood pressure is increased.
Bleeding problems. Remodulin may increase the risk of bleeding in people who take blood thinners (anticoagulants).

What are the possible side effects of Remodulin?

In clinical studies of SC infusion of Remodulin, most people experienced infusion site pain and infusion site reaction (redness, swelling, and rash). These symptoms were sometimes severe and sometimes required treatment with narcotics or discontinuation of Remodulin.
IV infusion of Remodulin delivered through an external pump has been associated with the risk of blood stream infections, arm swelling, tingling sensations, bruising, and pain.
The most common side effects seen with either SC or IV Remodulin were headache, diarrhea, nausea, rash, jaw pain, widening of the blood vessels (vasodilatation), and swelling from fluid retention (edema). These are not all the possible side effects of Remodulin. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at www.fda.gov/MedWatch or call 1-800-FDA-1088.

What is Remodulin?

In people with PAH who need to switch from epoprostenol, Remodulin is approved to slow the worsening of symptoms.

REMISIconFEB2025

PAH=pulmonary arterial hypertension; WHO=World Health Organization.