Infusion Site Management
Managing site pain and reactions
If you are on subcutaneous (SC) Remodulin, it is common to experience infusion site pain and infusion site reaction. Infusion site reaction was defined as symptoms such as abnormal redness of the skin, inflammation, or rash. Site discomfort varies by patient and infusion site, but has been shown in small studies to be most intense around 2 to 5 days after a site change and to lessen about a week after a site change in some patients. Remember to talk with your doctor about any discomfort or reaction you may have.
When you first begin Remodulin SC, it can be helpful to start your therapy on the stomach area so you can more easily monitor the site and apply remedies as necessary. Ask your doctor when and how often he or she recommends you change sites.
Working with your healthcare team, make a plan for how to manage any site pain you may have. This may include simple, over-the-counter remedies, or it may require prescription medicine. Record your experiences with site pain or reactions in your Remodulin Patient Journal, and share this information with your healthcare team. Working together, you can discover the best way to manage any future site pain or reactions before they occur.
Tips for choosing the best sites
In case of continued discomfort, speak to your doctor about moving to a new site.
- Backs of the upper arms
- Hip area
- The upper buttocks
- Stretch marks
- Scar tissue
- Under the waistband of clothing
- Folds of the belly
- Create a dry site (one that is not connected to your pump) if you think your site will need changing in the next couple of days. You can do this by inserting a new catheter in a different location from your current site and waiting at least 24 hours before hooking the new site up to your pump
- Talk to your doctor about any preventive measures you can take to help manage any site reactions or site pain
- Discuss with your doctor any over-the-counter and/or prescription medicines to help you manage any site reactions or pain
Potential remedies for site pain and reaction
The following approaches and products are some of the strategies that patients and doctors have reported as helpful in managing infusion site reactions associated with using Remodulin SC. United Therapeutics does not recommend or endorse using healthcare products other than as directed or prescribed.
There are several over-the-counter medications that may help you with site pain or reactions. There are also non-prescription topical solutions that may help you ease site pain or discomfort. Be sure to speak with your doctor to determine what might work best for your particular needs. Always consult the prescribing information of the product you choose to read about possible side effects and important safety information.
If one or more of the solutions above does not ease your site pain or reaction, there are several prescription pain relievers and topical solutions that might be helpful. Speak with your doctor to determine if you might benefit from a prescription medication to treat your site pain or reaction.
Selected Important Safety Information
What are the serious side effects of Remodulin?
- Continuous intravenous (IV) infusions of Remodulin delivered using an external infusion pump, with a tube placed in a central vein within the chest, are associated with the risk of blood stream infections and sepsis, which may be fatal. Therefore, continuous subcutaneous (SC) infusion delivered just beneath the skin is the preferred type of delivery.
- Worsening of PAH symptoms. Do not stop taking or greatly reduce your Remodulin dose without consulting your doctor.