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Treatment with Remodulin

Why Remodulin?

Because you’ve got more to do. And, you want to be able to do more of the things that make you who you are. With Remodulin, you get a treatment that can help improve your ability to exercise and reduce PAH symptoms, such as shortness of breath and fatigue.

Since 2002, Remodulin has been helping patients do more. As the most prescribed pump therapy for PAH, Remodulin has been trusted by patients and their doctors time and time again.

With Remodulin, you are not alone. You also have access to support programs and resources from United Therapeutics, a company founded to support people with PAH to help you get the most from therapy.

How will Remodulin change my day-to-day life?

Incorporating pump therapy into your life might feel intimidating at first, but it is possible and may get easier over time with the help of your healthcare team. Some people say that pump therapy allows them to think less about treatment because they don’t have to remember to take medicine during the day—the pump does all the work.

Remember, you have healthcare providers, Specialty Pharmacy, friends and family, and connections from PAH support groups who can help support you every step of the way. This team can help you with all aspects of day-to-day management of PAH and your treatment, including tips and advice to help you get used to having a pump. By staying with your therapy, you may be able to reduce your symptoms so you are able to do more in your daily life.

There are many things you can do to help make Remodulin a part of your daily life.

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How is Remodulin administered?

Remodulin is delivered through a pump system. With Remodulin, you get continuous delivery of medicine 24 hours a day, 7 days a week, so you know you’re getting the medicine you need. Administering Remodulin may take some getting used to, but just take it step-by-step until you feel comfortable.

Remodulin has different routes of administration:

Subcutaneous (SC) Administration:

Remodulin is delivered to the body via a very thin tube (cannula) not much thicker than a thread that is inserted just beneath the skin.

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Intravenous (IV) Administration:

Remodulin is delivered directly into the bloodstream via a narrow flexible tube called a catheter that is placed directly into a vein in your upper chest area.

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Implantable System For Remodulin:

An implanted intravenous pump is in development for Remodulin patients.*

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Your doctor will recommend the best delivery option for you.

There are also different pump options available for the delivery of Remodulin.

*FDA requires that certain conditions of Medtronic’s PMA approval of the Implantable System for Remodulin must be satisfied prior to launch or sale of the Implantable System for Remodulin; accordingly, Implantable System for Remodulin labeling may be revised in the process of satisfying such conditions of approval.

PMA=premarket approval.

How does Remodulin work?

In PAH, the body does not produce enough prostacyclin, a natural substance that keeps blood vessels open and working properly.

Remodulin acts like natural prostacyclin in your body to help keep the blood vessels in your lungs open. This may make it easier for your heart to pump blood through your lungs and help lessen your symptoms of PAH. Because Remodulin is delivered continuously, it provides the prostacyclin your body needs throughout the day.

What are the side effects with Remodulin?

  • With SC infusion of Remodulin, most people experience infusion site pain and infusion site reaction (redness, swelling, and rash)
  • With IV infusion of Remodulin delivered through an external pump, there is a risk of bloodstream infections, arm swelling, tingling sensations, bruising, and pain
  • The most common side effects seen with either SC or IV Remodulin are headache, diarrhea, nausea, rash, jaw pain, widening of the blood vessels (vasodilatation), and swelling from fluid retention (edema). These are not all the possible side effects of Remodulin

It is not unusual to experience side effects when taking Remodulin. Be sure to talk to your doctor about what to expect from treatment with Remodulin so you are prepared.

Together, you and your doctor can create a proactive plan to help treat side effects. There are medicines and methods your doctor can recommend to help manage side effects that occur with Remodulin and help you stay on therapy.

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View helpful information about living with Remodulin

  • Understand how pump therapy works with Remodulin
  • Learn about how Remodulin is different and the benefits and risks associated with it
  • Find information on living with PAH and what to expect from Remodulin

It can be helpful to talk to other patients about what tools they used and to find a network of support during treatment.

Remodulin® (treprostinil) Injection

Important Safety Information for Remodulin

Before you take Remodulin, tell your healthcare provider if you:

What are the serious side effects of Remodulin?

What are the possible side effects of Remodulin?

You may report side effects to the FDA at www.fda.gov/MedWatch or call 1-800-FDA-1088.

The risk information provided here is not comprehensive.

What is Remodulin?

Remodulin is a prescription medication used to treat adults with pulmonary arterial hypertension (PAH; WHO Group 1), which is high blood pressure in the arteries of your lungs. Remodulin can reduce symptoms associated with exercise. Remodulin was studied mainly in patients with NYHA Functional Class II-IV symptoms. It is not known if Remodulin is safe and effective in children.

In people with PAH who need to switch from epoprostenol, Remodulin is approved to slow the worsening of symptoms.

REMISIconOct19

To learn more about Remodulin, talk with your healthcare provider. Please see Full Prescribing Information at www.remodulin.com or call Customer Service at 1-877-UNITHER (1-877-864-8437).

PAH=pulmonary arterial hypertension; WHO=World Health Organization.

Remodulin® (treprostinil) Injection

Important Safety Information for Remodulin

Before you take Remodulin, tell your healthcare provider if you:

What are the serious side effects of Remodulin?

What are the possible side effects of Remodulin?

You may report side effects to the FDA at www.fda.gov/MedWatch or call 1-800-FDA-1088.

The risk information provided here is not comprehensive.

What is Remodulin?

Remodulin is a prescription medication used to treat adults with pulmonary arterial hypertension (PAH; WHO Group 1), which is high blood pressure in the arteries of your lungs. Remodulin can reduce symptoms associated with exercise. Remodulin was studied mainly in patients with NYHA Functional Class II-IV symptoms. It is not known if Remodulin is safe and effective in children.

In people with PAH who need to switch from epoprostenol, Remodulin is approved to slow the worsening of symptoms.

REMISIconOct19

To learn more about Remodulin, talk with your healthcare provider. Please see Full Prescribing Information at www.remodulin.com or call Customer Service at 1-877-UNITHER (1-877-864-8437).

PAH=pulmonary arterial hypertension; WHO=World Health Organization.